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Treating Laryngeal and Hypopharyngeal Cancer
If you've been diagnosed with laryngeal (voice box) or hypopharyngeal (lower throat) cancer, your care team will talk with you about your treatment options. It's important to weigh the benefits of each option against the possible risks and side effects.
Who treats laryngeal and hypopharyngeal cancers?
Based on the stage and location of your tumor, your treatment team may include an:
- Otolaryngologist who treats certain diseases of the head and neck. This type of specialist is also known as an ear, nose, and throat (ENT) doctor.
- Oral and maxillofacial surgeon, a dental surgeon who treats diseases of the mouth, teeth, and jaws.
- Radiation oncologist who treats cancer with radiation therapy.
- Medical oncologist who treats cancer with medicines such as chemotherapy, immunotherapy, or targeted therapy.
- Plastic surgeon who specializes in reconstructing or repairing parts of the body.
You might have many other specialists on your treatment team as well, including physician assistants (PAs), nurse practitioners (NPs), nurses, psychologists, nutritionists, social workers, dentists, speech and swallowing therapists, and other health professionals.
Because these cancers are located near many critical structures in your head and neck, it’s very important to go to a cancer center that has experience treating them.
How are laryngeal and hypopharyngeal cancers treated?
After laryngeal or hypopharyngeal cancer is found and staged, your cancer care team will discuss treatment options with you. Depending on the stage of the cancer, your overall health, and other factors, your treatment options may include:
Common treatment approaches
Several different treatments may be used for laryngeal and hypopharyngeal cancers. These treatments might be given alone or in combination.
Treatment options for these cancers often depend on the stage and location of the tumor. Your cancer care team will also consider your general health and personal preferences.
A major focus of treatment is trying save your larynx and voice if possible. Most experts do not recommend surgery that will totally remove the larynx unless there are no other options.
- For early-stage cancer, common treatments include radiation or larynx-preserving surgery.
- For later-stage cancer, treatment may include chemotherapy, immunotherapy, or targeted therapy.
Making treatment decisions
It’s important to discuss all your treatment options with your cancer care team. This includes talking about the goals and possible side effects of each treatment.
Ask questions if you are unsure about anything.
Questions to ask before laryngeal or hypopharyngeal cancer treatment
Understanding your diagnosis and choosing a treatment plan
- What are my treatment options?
- Is surgery part of my treatment?
- What is the goal of these treatments?
- What are the chances my cancer can be cured with these treatments?
- What do you recommend and why?
- How much experience do you have treating this type of cancer?
- How quickly do we need to decide on treatment?
- Should I get a second opinion? How do I do that?
What to expect during treatment
- What should I do to be ready for treatment?
- How long will treatment last?
- What will it be like? Where will it be done?
- How will treatment affect my daily activities? Can I still work full time?
- Can I exercise during treatment? If so, what kind should I do and how often?
- Are there any limits on what I can do?
- How will we know if the treatment is working?
- What are my options if it does not work or if the cancer comes back (recurs) after treatment?
Side effects and long-term effects
- What are the risks and side effects of the treatments you suggest?
- How long are these side effects likely to last?
- Are there things I can do to manage or reduce them?
- What symptoms or side effects should I tell you about right away?
- How can I reach you on nights, holidays, or weekends?
- Do I need to change what I eat during treatment?
- Should I see a genetic counselor to guide future screening for myself and my family?
- If I want children in the future, does this treatment affect my fertility and family planning?
Support and resources
- What if I don’t have transportation to and from treatment?
- Can you suggest a mental health professional if I start to feel overwhelmed, depressed, or distressed?
- What if I need social support during treatment because my family lives far away?
- Who do I talk to if I’m concerned about the costs and insurance coverage for my treatment?
Nutrition and supportive care
Getting the right nutrition to stay healthy is important if you have head and neck cancer. The cancer and its treatment can make it hard to swallow, eat, or drink. If this is true for you, you may need a feeding tube. This tube will probably be kept in place during treatment. Sometimes it might need to be left in longer.
Learn more about feeding tubes in Tubes and Drains Used in Cancer Treatment and Care.
Supportive care can ease your physical symptoms and help you cope with the feelings and changes in your life. You might also hear this called palliative care. Anyone diagnosed with a serious illness like cancer may benefit from this type of care. It can be given at any age and at any stage of the illness, anytime you need extra support or have symptoms that need to be controlled.
Learn more in Palliative Care.
Other things to consider
Quitting smoking: If you smoke, it is very important to try to quit before any treatment for laryngeal or hypopharyngeal cancer. Smoking can affect your treatment. It can cause a worse response to radiation therapy and make it harder for you to tolerate chemo. It can also lead to poor wound healing after surgery. Smoking after treatment can also increase your chance of getting another new cancer. The best way to improve your chance of survival is to quit smoking for good, before treatment starts if possible. It is never too late to quit. For help, see How To Quit Using Tobacco.
Seeking a second opinion: If time allows, consider getting a second opinion. This can give you more information and help you feel more confident about the treatment plan you choose.
Clinical trials: Clinical trials study new treatments and may offer access to promising options not widely available. They are also how doctors learn better ways to treat cancer. Ask your cancer care team about clinical trials you may qualify for.
Integrative (holistic) and alternative methods: You may hear about herbs, diets, acupuncture, massage, or other ways to relieve your symptoms or treat your cancer. Integrative therapies are used with standard care, while alternative ones replace it. Some of these may help with symptoms, but many aren’t proven to work. Some could even be harmful. Talk with your care team first to make sure they are safe and won’t interfere with treatment.
Choosing to stop treatment or choosing no treatment at all
When treatments have been tried and are no longer controlling your cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.
Choosing not to treat your cancer
Some people might not want to be treated at all, especially if the cancer is advanced. There are many reasons you might decide not to get treatment, but it’s important to talk to your cancer care team as you make that decision. Remember that even if you choose not to treat your cancer, you can still get supportive care to help with pain or other symptoms.
Hospice care
People with advanced cancer who are expected to live less than 6 months may want to consider hospice care. Hospice care is designed to provide the best possible quality of life for people near the end of life.
You and your family are encouraged to talk with your cancer care team about hospice care options, which include hospice care at home, a special hospice center, or other healthcare locations.
Nursing care and special equipment can make staying at home a workable option for many families.
The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask your cancer care team any questions you may have about your treatment options.
- Written by
- References
Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Amann J, Vetter D, Blomberg SN, Christensen HC, Coffee M, Gerke S, Gilbert TK, Hagendorff T, Holm S, Livne M, Spezzatti A. To explain or not to explain?—Artificial intelligence explainability in clinical decision support systems. PLOS Digit Health. 2022 Feb 17;1(2). https://doi.org/10.1371/journal.pdig.0000016
McCranie A, Lee AD, Leonard L, Vemuru S, Huynh V, D'Angelo J, D'Angelo AL, Ahrendt G, Kaoutzanis C, Fisher C, Gleisner A. Exploration of Patient Retention in Seeking a Second Opinion: A Retrospective Cohort Study. Journal of Surgical Research. 2025 Feb 1;306:588-603. https://doi.org/10.1016/j.jss.2024.04.025
Shah AP, Shi S, Shah S. Characterization of remote second-opinion oncology patients and associated changes in management. J Clin Oncol 40, e18563-e18563(2022). https://doi.org/10.1200/JCO.2022.40.16_suppl.e18563
Last Revised: May 28, 2026
American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.
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