Research We Fund: Extramural Discovery Science (EDS)

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Mission Boost Grants (MBG)

Grant Overview

Mission Boost Grants (MBG) are designed to support research projects that specifically focus on translation to human testing. MBGs are opportunities for independent investigators at all levels to apply for additional, or "boost," resources for innovative, clinical-enabling projects.

MBGs offer 2 stages of funding:

  • Stage I requires the investigator to develop outcome-specific, unequivocal milestones that reduce the risks of studying a new drug, device, or procedure in patients.??
  • Stage II supports testing in cancer patients.

Eligibility

Stage I Mission Boost

We no longer require MBG applicants to be current or former 大象tv grantees or fellows. Starting in 2025, you ARE eligible to submit a proposal if you:

  • Work at an academic institution in the United States or eligible nonprofit?
  • Are an independent investigator with a full-time faculty appointment (or equivalent). Applicants may be at any career stage.

Stage II Mission Boost

You ARE eligible to submit a proposal if you:

  • Work at an academic institution in the United States or eligible nonprofit?
  • Are an independent investigator with a full-time faculty appointment (or?equivalent). Applicants may be at any career stage.
  • Previously held or currently hold a Stage I Mission Boost Grant for a minimum of 18 months AND have completed Stage I milestones

Grant Term and Budget

Stage I Mission Boost?

Stage I will be for a term of up to 2 years with an allowable budget of $135,000 per year direct costs plus 10% allowable indirect costs ($297,000 allowable total costs).

Stage II Mission Boost

Stage II will be for a term of up to 18 months with an allowable budget up to $545,000 direct costs plus 10% allowable indirect costs.

Application Deadlines

June 1, 2025 and December 1, 2025

If the grant application deadline falls on a weekend or holiday, applications will be accepted the following business day.

All Grant Policies? ? ? ?All Grant Instructions????????

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Want to see some recently published studies from grantees?

Go to Research Highlights.