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If You Have Liver Cancer

If you or someone you know has just been diagnosed with liver cancer, this short guide can help. Find information on liver cancer here.

 

What is liver cancer?

Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer.

Liver cancer is a cancer that starts in the liver. It happens when cells in the liver start to change and grow out of control, crowding out normal cells. This makes it hard for the body to work the way it should.

The liver helps the body break down and use food after we eat. It also cleans your blood and helps your blood clot when you are cut.

Liver cancer cells can spread to other parts of the body. When cancer does this, it's called metastasis. Even if a liver cancer spreads to another part of your body, it is still liver cancer.

color illustration of the digestive system which shows the location of the esophagus, stomach, pancreas, transverse colon, descending colon, sigmoid colon, anus, rectum, appendix, cecum, ascending colon, small intestine, gallbladder and liver

The liver

Types of liver cancer

If a cancer starts in the liver, it is called primary liver cancer. There are many types of liver cancer. Some are very rare. Your doctor can tell you more about the type you have.The most common type of liver cancer is hepatocellular carcinoma (HCC). It starts in the cells that make up the liver.

Some rare types of liver cancer are:

  • Angiosarcoma
  • Hemangiosarcoma

These cancers start in the cells lining the blood vessels of the liver. They often grow quickly.

Questions to ask the doctor about the type of cancer you have

  • Why do you think I have liver cancer?
  • Is there a chance I don’t have liver cancer?
  • Would you please write down the kind of cancer you think I might have?
  • What will happen next?

How does the doctor know I have liver cancer?

Liver cancer often doesn’t cause signs and symptoms until it has grown very large or spread.

Some symptoms of liver cancer are:

  • Unplanned weight loss
  • Not feeling like eating
  • Feeling full after a small meal
  • Belly pain and swelling
  • Itchy, yellow skin or eyes

The doctor will ask you questions about your health and examine you.

Tests that might be done

If signs are pointing to liver cancer, more tests may be done. Here are some of the tests you might need:

Ultrasound: For this test, a small wand is moved around on your skin. It gives off sound waves and picks up the echoes as they bounce off tissues. The echoes are made into a picture on a computer screen. This test is often the first test used to look at the liver.

CT or CAT scan: This scan uses x-rays to make detailed pictures of your body. It can show the size, shape, and place of any tumors in or near the liver.

MRI: This scan uses radio waves and strong magnets instead of x-rays to make detailed pictures. MRI can help tell if tumors in the liver are cancer. It can also be used to look at blood vessels in and around the liver, and to help find out if liver cancer has spread.

Lab tests: Blood tests can check a protein called AFP (alpha-fetoprotein). AFP levels often are very high in people with liver cancer. Other blood tests can also help find out how well the liver is working.

Liver biopsy: In a biopsy, the doctor takes out small pieces of body tissue where the cancer seems to be. The tissue is checked for cancer.

There are many types of biopsies. Ask your doctor what kind you will need. Each type has risks and benefits. The choice of which type to use depends on your own case.

Sometimes MRI or CT scans clearly show liver cancer, so a biopsy isn’t needed.

Questions to ask the doctor about tests

  • What tests will I need?
  • Who will do these tests?
  • Where will the tests be done?
  • How and when will I get the test results?
  • Who will explain the test results to me?
  • What do I need to do next?

How serious is my cancer?

If you have liver cancer, the doctor will want to find out how far it has spread. This is called staging. The stage describes the growth or spread of the cancer through the liver. It also tells if the cancer has spread to other organs near the liver or in other parts of the body. Your doctor will want to find out the stage of your cancer to help decide what type of treatment is best for you.

Staging the cancer

Your cancer can be stage 1, 2, 3, or 4. The lower the number, the less the cancer has spread. A higher number, like stage 4, means the cancer has spread outside the liver.

Doctors may also group liver cancers more simply, based on if they can be removed (resected) completely.

Be sure to ask about your cancer stage and what it means.

Questions to ask the doctor about the cancer’s stage

  • Do you know the stage of the cancer?
  • If not, how and when will you find out the stage?
  • Would you explain to me what the stage means in my case?
  • Based on the stage of the cancer, what are my treatment options?
  • What will happen next?

What kind of treatment will I need?

There are many ways to treat liver cancert, but the main types of treatment are:

  • Surgery
  • Tumor ablation
  • Embolization
  • Radiation 
  • Targeted therapy
  • Immunotherapy
  • Chemotherapy

Many times, more than one kind of treatment is used.

The treatment plan that’s best for you will depend on:

  • The stage of the cancer
  • How well your liver is working
  • The chance that a type of treatment will cure the cancer or help in some way
  • Your age and any health problems you have
  • Your feelings about the treatment and the side effects that come with it

Surgery for liver cancer

Surgery is the best way to try to cure liver cancer if it can be done. But not everyone with liver cancer can have surgery.

Surgery can be done to:

  • Take out the part of the liver with the tumor (partial hepatectomy)
  • Do a liver transplant

Talk to your doctor about the kind of surgery planned and what you can expect.

Side effects of surgery: Any type of surgery can have risks and side effects, such as bleeding or infections. Be sure to ask your cancer care team what you can expect. If you have problems, let your doctors know. Doctors who treat liver cancer should be able to help you with any problems that come up.

Ablation for liver cancer

Ablation is a treatment that destroys small liver tumors without taking them out. There are a number of ways to do this:

  • Heating the tumor with radio waves or microwaves
  • Freezing the tumor
  • Killing the tumor by putting alcohol in it

Talk to your doctor about the planned treatment and what you can expect.

Embolization for liver cancer

For embolization, a substance is injected into an artery in the liver to block or reduce the blood supply to the cancer. Some people with liver tumors that cannot be removed by surgery can have embolization. It can be used for tumors that are too large to be treated with ablation. Embolization can also be used with ablation.

There are different types of embolization:

  • Arterial embolization
  • Chemoembolization
  • Radioembolization 

But this treatment may not be a good choice for some people whose liver has been damaged by diseases like hepatitis or cirrhosis. 

Side effects of embolization: Possible side effects after embolization include abdominal (belly) pain, fever, nausea, infection in the liver, gallbladder inflammation, and blood clots in the main blood vessels of the liver.  Serious complications are not common, but they are possible. If your doctor suggests radiation treatment, ask what side effects might happen.

Radiation treatments

Radiation uses high-energy rays (like x-rays) to kill cancer cells. There are different kinds of radiation.

  • External beam radiation can be aimed at the liver from a machine outside the body.
  • Radioembolization (radiation and embolization) uses a needle to put small radioactive beads into the hepatic artery, a large blood vessel in the liver, so the radiation is very close to the cancer.

Side effects of radiation treatments: If your doctor suggests radiation treatment, ask what side effects you might have.

Side effects depend on the type of radiation that’s used. The most common side effects of radiation are skin changes where the radiation is given and feeling very tired. Most side effects get better after treatment ends. Some might last longer. Talk to your doctor about what you can expect.

Targeted drugs for liver cancer

Targeted drugs are different from chemotherapy drugs (see below). Targeted therapy drugs affect mainly cancer cells and not normal cells in the body. They may work even if other treatment doesn’t. They might come as pills that you can take at home, or they might be injected into your blood.

Side effects of targeted drugs: These drugs have different side effects from chemo. They depend on which drug is used. Ask your doctor what you can expect.

Immunotherapy

Immunotherapy uses medicines that help your immune system find and destroy cancer cells. Immunotherapy to treat liver cancer is usually given into a vein.

Side effects of immunotherapy: Immunotherapy can make you feel tired, sick to your stomach, or cause fever, chills, and rashes. Most of these problems go away after treatment ends.

Some side effects though are more serious than others.  Talk to your doctor about what you can expect.

Chemo

Chemo (chemotherapy) is the use of certain drugs to fight cancer. These drugs go into the blood and spread through the body. Chemo is given in cycles or rounds. Each round of treatment is followed by a break. Chemo may be used to treat liver cancer, but usually it doesn’t work as well as targeted drugs or immunotherapy.

A type of embolization that uses chemotherapy is known as chemoembolization. Tiny beads carrying chemo drugs are put into an artery to reduce blood flow to the tumor and also to put the chemo very close to the cancer.

Side effects of chemo: Chemo can make you feel very tired, sick to your stomach, and may cause your hair to fall out. But these problems tend to go away after treatment ends. There are ways to treat most chemo side effects. If you have side effects, tell your cancer care team so they can help.

Clinical trials

Clinical trials are research studies that test new drugs or other treatments in people. They compare standard treatments with others that may be better.

If you would like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials. See Clinical Trials to learn more.

Clinical trials are one way to get the newest cancer treatment. They are the best way for doctors to find better ways to treat cancer. If your doctor can find one that’s studying the kind of cancer you have, it’s up to you if you want to take part. And if you do sign up for a clinical trial, you can always stop at any time.

What about other treatments I hear about?

When you have cancer, you might hear about other ways to treat the cancer or treat your symptoms. These may be vitamins, herbs, special diets, and other things.

Some of these are known to help, but many have not been tested. Some have been shown not to help. A few have even been found to be harmful. Talk to your doctor about anything you’re thinking about using, whether it’s a vitamin, a diet, or anything else.

Questions to ask the doctor about treatment

  • What treatment do you think is best for me?
  • What’s the goal of this treatment? Do you think it could cure the cancer?
  • Will treatment include surgery? If so, who will do the surgery?
  • What will the surgery be like?
  • Will I need other types of treatment, too? What’s the goal of these treatments?
  • Where will these treatments be given?
  • What side effects could I have from these treatments?
  • What can I do about side effects?
  • Is there a clinical trial that might be right for me?
  • What about special vitamins or diets that friends tell me about? How will I know if they are safe?
  • How soon do I need to start treatment?
  • What should I do to be ready for treatment?
  • Is there anything I can do to help the treatment work better?
  • What’s the next step?

What will happen after treatment?

In some people, liver cancer might be removed or destroyed, but in others it might not go away completely. In either case, you still will need to see your cancer doctor. Be sure to go to all of your follow-up visits. Your doctor will ask about any symptoms that you might have, and you will have exams, blood tests, and maybe other tests.

At first, your visits may be every 3 to 6 months. Then, the longer you’re cancer-free, the less often the visits are needed.

Some treatments may not cure your cancer but may help slow its growth or help reduce symptoms and help with your quality of life. You might need to keep getting treatment and care. From time to time, tests will be done to see how your treatment is working.

Having cancer and dealing with treatment can be hard, but it can also be a time to look at your life in new ways.

Call us at 1-800-227-2345 or talk to your cancer care team to find out what you can do to feel better.

You can’t change the fact that you have cancer. What you can change is how you live the rest of your life.

For connecting and sharing during a cancer journey

Anyone with cancer, their caregivers, families, and friends, can benefit from help and support. The American Cancer Society offers the , a safe place to connect with others who share similar interests and experiences. We also partner with , a free online tool that helps people dealing with illnesses like cancer stay in touch with their friends, family members, and support network by creating their own personal page where they share their journey and health updates.   

 

 

 

For connecting and sharing during a cancer journey

Anyone with cancer, their caregivers, families, and friends, can benefit from help and support. The American Cancer Society offers the , a safe place to connect with others who share similar interests and experiences. We also partner with , a free online tool that helps people dealing with illnesses like cancer stay in touch with their friends, family members, and support network by creating their own personal page where they share their journey and health updates.   

side by side logos for American Cancer Society and American Society of Clinical Oncology

Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

 

Ablation (a-BLAY-shun): Treatment to destroy a tumor. Ablation may be done with drugs, radio waves, heat, cold, alcohol, or microwaves to treat liver cancer.

Angiosarcoma (AN-jee-o-sar-KO-muh)A type of cancer that starts in cells that line blood vessels or lymph vessels.

Biopsy (BY-op-see): Taking out a small piece of body tissue to see if there are cancer cells in it.

Hemangiosarcoma (hee-MAN-jee-oh-sar-KOH-muh): Cancer that starts in the cells that line blood vessels.

Hepatocellular carcinoma (heh-PA-toh-SEL-yoo-ler CAR-sih-O-muh): The most common type of liver cancer. It starts in liver cells.

Hepatectomy (HEH-puh-TEK-toh-mee): Surgery to take out all or part of the liver.

Metastasis (muh-TAS-tuh-sis): The spread of cancer from where it started to other places in the body.

Radiation (RAY-dee-AY-shun): Use of high-energy rays (like x-rays) to kill cancer cells.

Radioembolization (RAY-dee-oh-EM-boh-lih-ZAY-shun): A type of radiation therapy used to treat liver cancer in which tiny beads of radiation are put right into the hepatic artery, a big blood vessel in the liver.

 

 

 

We have a lot more information for you. You can find it online at www.cancer.org. Or, you can call our toll-free number at 1-800-227-2345 to talk to one of our cancer information specialists.

Last Revised: February 11, 2025

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